Friday Program

FRIDAY 5th MAY 2006

7.30-8.00

REGISTRATION AND COFFEE

8.00-10.00

Main Auditorium
PLENARY 4: SALT AND WATER IN RENAL DISEASE. Co-Chair: Tubular handling of sodium in health and renal disease. Guest Speaker: Fiona Karet, Professor, Wellcome Senior Clinical Fellow, University of Cambridge Diuretics are tubular toxins - are they ever safe to use? Guest Speaker: Liam Plant, Consultant Nephrologist, University Hospital of Cork, Eire The right balance of salt and water in kidney disease. Guest Speaker: Charlie Tomson, Consultant Nephrologist, Southmead Hospital, Bristol Using technology to determine dry weight in renal failure. Guest Speaker: Paul Chamney, Clinical Scientist, FMC, Germany

10.00-10.30

COFFEE & EXHIBITION - Hall Q

POSTERS - Hall D

10.30-12.00

Main Auditorium	Queens Suite 1	Queens Suite 2	Kings Suite
Patient Centred Care Co-Chair: Robert Dunn, NKF & Jane Macdonald, Hope Hospital, Salford Skills for Health – Transplant Competences. Guest Speaker: Lisa Burnapp, Consultant Nurse, Living Transplantation, Guy’s and St Thomas’s Hospital Trust, London O74 Identifying Patient Preferences for Pre-Dialysis Education Using Conjoint Survey J M Sedgewick, University of Teesside, Middlesbrough O75 Patient perspectives on chronic kidney disease caused by diabetes N Thomas, SW Thames Institute for Renal Research, Carshalton O76 The British Renal Society/Kidney Research UK patient information DVD project: results of the National Patient Survey R Adkins, Birmingham Heartlands Hospital O77 An Important New Tool to Renew Interest in Haemodialysis Patient Self-care N Gitsham, Modernisation Initiative, London	Clinico-pathological conference Co-Chair: Peter Furness , Leicester General Hospital, & Terry Cook Imperial College, London Clinical Discussant: Andy Rees, University of Aberdeen	Birth to Adolescence Chair: Maggie Fitzpatrick, St. James’s University Hospital, Leeds Pregnancy and renal disease – facts and fiction. Guest Speaker: David Williams, Senior Lecturer in Obstetric Medicine, University College London O78 Whole gene deletions of the hepatocyte nuclear factor-1 β gene are a common cause of renal cysts and other renal developmental disorders RA Oram, Royal Devon and Exeter Hospital O79 The development of a novel multidisciplinary Renal Genetic and Tubular Disorders clinic, and accompanying genetic tests. RN Sandford, Cambridge University Hospitals NHS Foundation Trust O80 Pregnancy Outcomes Post Kidney Transplantation, 5 Year Single Centre Experience A Boswell, Nottingham City Hospital O81 Prognostic Factors of Posterior Urethral Valves K McKeever, Royal Hospitals, Belfast Transitional Care. Guest Speaker: Donna Hilton, Senior Youth Worker, Nottingham City Hospital	Renal Scientists Forum Co-Chair: Alice Smith, Leicester General Hospital & Julie Williams, The Medical School, Birmingham University O82 Albumin induced IL-6 release requires P13K and ERK1/2 in primary human PTEC A Pearson, SW Thames Institute for Renal Research, Carshalton O83 NK-ĸB and STAT Signalling play a central role in the development of peritoneal fibrosis following recurrent inflammation CA Fielding, School of Medicine, Cardiff University O84 Macrophages, nitric oxide and interstitial inflammation T Kipari, Queen’s Medical Research Institute, Edinburgh O85 Bone marrow-derived cells contribute to podocyte regeneration in a mouse model of Alport’s syndrome EI Prodromidi, Imperial College London Inflammation from Cytokines to Fibrosis. Guest Speaker: Nicholas Topley, Institute of Nephrology, Cardiff Presentation of Young Scientist Award

12.00-13.30

LUNCH & EXHIBITION - Hall Q

MODERATED POSTER SESSION – Hall D

13.30-15.00

Main Auditorium	Queens Suite 1	Queens Suite 2	Kings Suite
Cardiovascular Risk in CKD *Sponsored by Genzyme* Chair: David Wheeler, Royal Free & University College Medical School, London Cardiovascular risk and CKD – which is the chicken and which the egg? Guest Speaker: Charlie Ferro, Consultant Nephrologist, Queen Elizabeth Hospital, Birmingham O86 Reduced Baroreflex Sensitivity Associated with Increased Arterial Stiffness in CKD 4 is Only Present in Patients With Vascular Calcification LJ Chesterton, Derby City General Hospital O87 Weight loss predicts albuminuria regression in a General Population: An Observational Study AK Bello, Sheffield Kidney Institute O88 Functionally significant vascular calcification is rapidly progressive in CKD 4 and 5 patients MK Sigrist, Derby City General Hospital O89 Chronic Renal Insufficiency Standards Implementation Study: 2yr Follow-up Data RJ Middleton, Hope Hospital, Salford	Patient Involvement Chair: Julie Daniels, Kent & Canterbury Hospital & Steve Smith, Birmingham Heartlands Hospital, President, BRS Developing Patient Involvement in Renal Services. Guest Speaker: Robert Dunn, National Patient Advocate, National Kidney Federation Providing a Patient Centred Renal Transport Service. Guest Speaker: Jenny Scott, Head of Specialised Commissioning, Chester & Merseyside O90 Is Patient Choice A Reality? N Thomas, SW Thames Renal and Transplantation Unit, Carshalton O91 Myths and Reality of Attitudes to Hypertension in South London J Ferguson, The Modernisation Initiative, London	Renal Association Raine Awards Chair: John Feehally, Leicester General Hospital, President, The Renal Association 2005 Raine Awardee Atypical HUS – an evolving story. Guest Speaker: Anna Richards, Fulbright Distinguished Scholar, Washington University Medical School, St Louis, USA 2006 Raine Awardee Immune Inhibition: Infection versus Autoimmunity. Guest Speaker: Meena Clatworthy, Department of Renal Medicine, Addenbrooke’s Hospital, Cambridge	Vasculitis Chair: Peter Mathieson, Southmead Hospital, Bristol O92 Circulating macrophage mannose receptor is elevated in acute systemic vasculitis and plays a critical role in development of experimental glomerulonephritis K Chavele, Imperial College London O93 CT60 A-G and +49 A-G Polymorphisms of CTLA4 Gene are Associated with Small Vessel Vasculitis L Kamesh Medical School, University of Birmingham O94 Predictors of outcome of Pauci-Immune renal vasculitis: analysis of 390 patients over twenty years CJ Day, Medical School, University of Birmingham O95 Predictors of Outcome in Pauci-Immune Renal Vasculitis with Severe Renal Impairment P Hewins, Medical School, University of Birmingham O96 Relapse and long-term outcome of patients with primary systemic vasculitis. A 30-year single centre experience M Ryba, Imperial College London O97 B Cell Depletion with Rituximab Treatment for Vasculitis. RB Jones, Addenbrooke’s Hospital, Hills Road, Cambridge

15.00-15.30

COFFEE BREAK - Hall Q

15.30-17.30

Main Auditorium

Queens Suite 1

Plenary 5: Acute Renal Failure.
Chair: Andrew Davenport, Royal Free Hospital, London & Natasha McIntyre, Nottingham City Hospital

New insights into the pathophysiology of acute kidney injury.
Guest Speaker: Joseph Bonventre, Chief, Renal Division. Brigham and Women’s Hospital, Boston, USA

Is acute renal failure avoidable in the majority of cases?
Guest Speaker: Paul Stevens, Consultant Nephrologist, Kent & Canterbury Hospital

Acute renal failure in children – causes and outcomes.
Guest Speaker: Mark Taylor, Consultant Paediatric Nephrologist, Birmingham Children’s Hospital

Renal replacement therapy for ARF – which technique in which situation.
Guest Speaker: Raymond Vanholder, Professor of Renal Medicine, University of Gent, Belgium

Laboratory Science: Basic General Science
Chair: Kevin Harris, Leicester General Hospital

O98 O-glycosylation of serum IgD in IgA nephropathy
AC Smith, Leicester General Hospital

O99 Interleukin-11 Downregulates transforming growth factor (TGF) Beta 1, α-Smooth Muscle Actin (SMA) and fibronectin in nephrotoxic nephritis in Wistar Kyoto (WKY) rats
F. K. Tam, Imperial College of Medicine, London

O100 Withdrawn

O101 De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical haemolytic uraemic syndrome
THJ Goodship, Centro de Investigacions Biologicas, Madrid, Spain

O102 Haemolytic uraemic syndrome: functional consequences of novel mutations in complement factor H
SA Johnson, University of Birmingham

O103 Downregulation of TRPC6 by intact nephrin in the presence of human plasma – a protective mechanism for maintenance of podocyte morphology
R Lennon, University of Bristol

O104 Over-expression of the podocyte derived VEGF isoform – VEGF₁₆₅b – slows renal cell tumour growth in vivo
SJ Harper, University of Bristol

O105 Non obese diabetic mice exhibit reduced clearance of apoptotic cells in vivo
KAN Houlbert, Queens Medical Research Institute, Edinburgh

17.30

MEETING CLOSES

BRS/RA Integrated Conference Programme 2006