BRS/RA Integrated Conference
Wednesday 14th May 2008: CKD Day

 Tuesday 13th May

 Wednesday 14th May

  Thursday 15th May

  Friday 16th May

8.30 REGISTRATION
  CORPORATE SESSIONS
8.45 – 9.45

Alsh

Boisdale

Carron

BREAKFAST
SESSIONS

ROCHE

ERYTHROPOESIS STIMULATING AGENTS: PROCESS IS THE PRODUCT?

08.45-08.50 Welcome
08.50-09.05 Erythropoiesis Stimulating Agents (ESAs) production process
• Background on biotechnology
09.05-09.20 Immunology
• Points for consideration
09.20-09.35 Therapeutic & regulatory framework for ESAs
• EMEA biosimilar regulatory guidelines vs EPAR data and substitution
09.35-09.45 Ask the expert panel discussion
09.45 Closing remarks

ABBOTT

NEW EMERGING ASPECTS FOR VITAMIN D RECEPTOR ACTIVATORS IN THE TREATMENT OF SHPT

Invited Speaker: Daniel Zehnder , Consultant Nephrologist & Senior Clinical Lecturer, University Hospital Coventry & Warwickshire
Invited Speaker: Ravi Thadani, Massachusetts General Hospital, Boston, USA

SANOFI AVENTIS

BLOOD PRESSURE MANAGEMENT IN RENAL DISEASE

Invited Speaker: Damian Fogarty, Consultant/Senior Lecturer, Belfast City Hospital

10.00- 12.00 Lomond Auditorium

CHRONIC KIDNEY DISEASE (RENAL RISK)
Chairs: Paul Stevens and Peter Mathieson

CKD and Progression
Invited
Speaker: Maarten Taal, Consultant Renal Physician, Derby Hospitals NHS Foundation Trust

O1The development of a sequential algorithm to assess stability of renal function in patients with CKD
Chris Farmer, Consultant Nephrologist, Kent and Canterbury Hospital

O2 Management of CKD at the interface between primary and secondary care: The Bradford CKD Electronic Advisory Service (CKDEAS)
Chee Kay Cheung, Specialist Registrar, Bradford Teaching Hospitals NHS Trust

O3 Increased proteinuria despite equality of care in South Asians with Type 2 diabetes mellitus
Matthew Hall, Specialist Registrar, Leicester General Hospital

O4 (was 296) Prediction of End-Stage Renal Disease and Mortality among patients with pre-dialysis CKD: The Chronic Renal Impairment in Birmingham (CRIB) cohort
Tanaji Dasgupta Clinical Research Fellow, University of Oxford

O5 Prediction of progression of CKD within the first year post liver transplantation: defining indications for combined liver kidney transplantation
Aisling O’Riordan, Clinical Research Registrar, Kings College Hospital

06 Tubular dysfunction with low circulating levels of Erythropoietin and 1,25 (OH) 2 D3 occurs early in Diabetics with normal GFR
Dhruv Singh, Lister Hospital, Stevenage

                         Alsh
COMPLICATIONS OF DIALYTIC THERAPY
Chair: Ken Farrington

O7 A collaborative approach to reducing Tunnelled HD Catheter related bacteraemia (THCRB)
Clare Miller, Acting Matron for Hospital & Community HD, Guy’s & St Thomas’ Hospital

O8 Clinical course and management of Encapsulating Peritoneal Sclerosis: a Multicentre Retrospective Survey by the Pan-Thames Audit Group
Gowrie Balasubramaniam, Specialist Registrar, Hammersmith Hospital

O9 Adaptation of the ‘Derby Gentamicin/Heparin Catheter Lock Protocol’ results in a 10 fold reduction in incidence of catheter related bacteraemia
Rommel Ravanan, Consultant Nephrologist & Transplant Physician, University Hospital of Wales

O10 Peritonectomy is a successful treatment for patients with Encapsulating Peritoneal Sclerosis (EPS) following Renal Transplantation
Angela Summers, Post Doctural Renal Scientist, Manchester Royal Infirmary

O11 Cuffed venous catheter bacteraemia – outcome after attempted salvage
Damien Ashby, Specialist Registrar, Hammersmith Hospital

O12Encapsulating peritoneal sclerosis in Scotland – A retrospective case series
Michaela Brown, Specialist Registrar, Royal Infirmary Hospital, Glasgow

O13 The rise of Vancomin Resistant Enterococci (VRE) in renal units
Nitish Khanna, Specialist Registrar, Western Infirmary, Glasgow

O14 Serum Cardiac Troponin-T Concentrations are associated with outcome in patients with HD induced Myocardial Stunning
James Burton, Research Registrar, Derby City General Hospital

                  Boisdale UPDATE IN TRANSPLANTATION TECHNOLOGY
Chair: Roger Moore

How does UK Transplant allocate donated kidneys? How do the kidneys get to the recipients?
Invited Speaker: Rachel Johnson, Principal Statistician UK Transplant & Joyce Curwen, Transplant Co-ordinator, Freeman Hospital, Newcastle

Live donor transplants – ethical issues, tissue matching, the new technology that allows transplantation despite ABO incompatibility
Invited Speakers: Sue Moore, Lead Living Kidney Donor Transplant Co-ordinator, University Hospital Birmingham & Anne- Marie Phythian, Renal Operational Support Sister, University Hospital Birmingham

Non-heart beating donors – logistics of providing the service and preserving the kidneys
Invited Speaker: David Talbot, Freeman Hospital, Newcastle

                     Carron
YOUNG RENAL SCIENTIST FORUM
Chair: John Reynolds and Heather Wilson

Viral vectors, targeted gene therapy and kidney disease
Invited Speaker: Andrew Baker, Professor of Molecular Medicine, University of Glasgow

2nd judge: Paul Evans, Senior Lecturer, National Heart & Lung Institute, Imperial College, London

O15 CDP/cux is a novel modulator of collagen Type 1 and is capable of strong inhibition of the COL1A2 Gene
Maria Fragiadaki, PHD Student, Imperial College London

O16 Angiopoietin-1 therapy maintains kidney peritubular capillaries but enhances fibrosis and inflammation after folic acid-induced acute renal failure
David Long, Post Doctural Research Fellow, UCL Institute of Child Health

O17 Role of N-methyl-D-aspartate receptor (NMDA-R) in renal epithelial-mesenchymal transition in vitro
Milica Bozic, PHD Student, University Hospital Arnau de Vilanova, Spain

O18 The protemic analysis of rat urine following subtotal nephrectomy (SNX)
Melissa Vickers, PHD Student, University of Sheffield

O19 Aldosterone activates ERK1,2 signalling in proximal tubular epithelial cells
Alex Pearson, Post Doctoral Research Fellow, St Helier Hospital, Carshalton

O20 A role for diacylglycerol kinase and phosphatidyl-Inositol-3-kinase in the release of primary granules from ANCA stimulated neutrophils
Neil Holden, Post Doctoral Fellow, University of Birmingham

                Dochart CPD SESSION –
GLOMERULAR DISEASE

Chairs: Jeremy Levy & Sue Carr

New Developments in Treating Vasculitis
Invited Speaker: Lorraine Harper,
Senior Lecturer and Honorary Consultant, University of Birmingham

Evaluation & Treatment of Steroid Resistant Nephrotic Syndrome
Invited Speaker: Alain Meyrier,
Service De Nephrologie, Hospital Broussais, Paris

The Podocyte; Its Failure, Its Genes and Nephrosis
Invited Speaker: Moin Saleem,
Consultant Paediatric Nephrologist
Bristol Royal Hospital For Children

Interactive clinical case presentation
Case1 – A case of steroid resistant NS
Case 2 – A case of vasculitis

Case Discussion with
Prof John Feehally and
Prof Alan Meyrier

12.00-13.30 LUNCH & EXHIBITION & CORPORATE SESSIONS
12.15-13.15

LUNCHTIME
SESSIONS

                                 Alsh
ROCHE
DRIVING EFFICIENCIES IN THE CARE OF DIALYSIS PATIENTS

12.15 Foreword
Meeting objectives and format
NHS initiatives for improving efficiencies in care
The rising burden of CKD and the need to challenge current practice

12.30 Driving efficiencies: Patient transport
How can we improve transport to and from dialysis?

12.40 Driving efficiencies: Dialysis scheduling
How can we make the dialysis process more efficient?

12.50 Driving efficiencies: Additional measures
How we can reduce time spent on additional tests?

13.00 Driving efficiencies: The benefits
Opportunities for improving patient care

13.10 Meeting Summary

13.15 Close

                             Boisdale
SHIRE
KIDNEY CARE – ACHIEVING ADHERENCE IN PHOSPHATE MANAGEMENT

12.15 - Chairmans Introduction
Dr Alastair Hutchinson, Consultant in
Nephrology, Manchester Royal Infirmary

12.20 - An update on Fosrenol
Dr Alastair Hutchinson

12.30 - Using protocols and patient group directions to
extend the dietitian’s role in managing
phosphate levels
George Hartley, Lead Renal Dietician
Freeman Hospital, Newcastle-upon-Tyne

12.45 - Coaching tips for the renal healthcare
professional
Liz Rogers, Leadership and Team
Development Coach

13.05 - Question and answer session

                            Carron
BAPN BUSINESS MEETING
                     Dochart
AMGEN
NEW DEVELOPMENTS IN THE MANAGEMENT OF CKD PATIENTS

Chair: Chris Winearls

Algorithm to optimise the treatment of anaemia and the achievement of Hb stability
Invited Speaker: Dr Donald Richardson, York

Managing SHPT in the modern era: new tools, new questions.
Invited Speaker: Dr Mark Macgregor

13.30- 15.00
                                                   Lomond Auditorium
RENOVASCULAR DISEASE - DAWN OF THE ERA OF EVIDENCE?
Chairs: David Goldsmith & Alan Jardine

The ASTRAL trial
Invited Speaker: Phil Kalra, Consultant Nephrologist, Salford Royal Hospitals NHS Trust

New Applications of MR imaging in ARVD
Invited Speaker: G Houston, Consultant Interventional Radiologist, Ninewells Hospital, Dundee

Prediction of renal functional outcome after revascularization in ARVD
Invited speaker: C Cheung, Specialist Registrar, North West Rotation

Latest insights into the epidemiology of ARVD
Invited speaker: RN Foley, Associate Professor of Medicine, Memorial University, Minneapolis, U.S.A.

                                                                  Carron IMMUNOLOGICAL RENAL DISEASE AND AKI
(Renal Science)
Chairs: Charles Pusey & Magdi Yaqoob

O21 Renal Cell Toll-Like Receptor stimulation triggers Crescentic Glomerulonephritis
Michael Robson, Senior Lecturer, Kings College London

O22 Slit2 impairs monocyte chemotaxis and renal expression is downregulated in acute allograft rejection
Meeta Mallik, Paediatric Nephrology Research Fellow, Hospital for Sick Children, Toronto, Canada

O23 Acute kidney injury: Differential modulation by monocyte/macrophage depletion and apoptotic cells
David Ferenbach, Clinical Training Fellow, University of Edinburgh

O24 Induction of monocyte and macrophage apoptosis ameliorates microvascular injury in murine renal allograft rejection
David Ferenbach, Clinical Training Fellow, University of Edinburgh

The Regulation of Inflammation by Ubiquitination
Invited Speaker: Paul Evans, Senior Lecturer, National Heart & Lung Institute, Imperial College, London

15.00-16.00 COFFEE & EXHIBITION                     MODERATED POSTER SESSION                                          POSTERS
16.00-17.30
 Lomond Auditorium

ASPECTS OF CKD IN PRIMARY CARE
Chair: Nicola Thomas

How CKD management has changed in the past two years
Invited speaker: Karen Jenkins, Consultant Nurse, Kent & Canterbury Hospitals

The effect of guidelines and eGFR
Invited speakers:
Edmund Lamb & Ian John, Consultant Nephrologists, Kent & Canterbury Hospitals

The challenge of education: e-learning tools in CKD
Invited speaker: Robert Lewis, Consultant Nephrologist, Wessex Regional Renal & Transplant Unit

Emerging models of care: Where we are now, comparing differing models of care in CKD
Invited speaker: Kathryn Griffith, GP, University Health Centre, York University

Where we should be – GP perspective
Invited speaker: Ian Wilkinson, GP, Oldham
 

                         Alsh

BRS RESEARCH FORUM
Chair: Simon Ball

Broadening Options for Long-term Dialysis in the Elderly (BOLDE): life on HD compared to PD
Invited Speaker: Edwina Brown, Consultant Nephrologist, Hammersmith Hospital

Facilitating dietary change in renal disease; investigating patient’s perspectives
Invited Speaker : Debbie Sutton, Renal Research Dietician, Queen Alexandra Hospital, Portsmouth

A prospective randomized study to evaluate the use of pre and postoperative ultrasound in terms of predicting the maturation and patency of arteriovenous fistulae for haemodialysis
Invited Speaker: Martin Ferring, Renal Specialist Registrar, Birmingham Heartlands Hospital

The effects of oral sodium bicarbonate on extracellular water in patients with Chronic Renal Failure
Invited Speaker: Colin Jones, Consultant Renal Physician, York Hospital

More time, better outcome – a randomized trial investigating the effect of more dietetic time on phosphate levels in end-stage renal failure patients
Invited Speaker: Rebecca Walker, Senior Renal Dietician, Royal Free Hospital, London

                Boisdale

RENAL REGISTRY
Chair: Charlie Tomson

Registry Update
Invited Speaker: David Ansell

Pre RRT factors influencing 1st year outcomes on RRT
Invited Speaker: Dan Ford

Understanding the ‘centre’ effect
Invited Speaker: Alex Hodsman

Donor factors in the prediction of CKD in transplant recipients
Invited Speaker: Uday Udayaraj

A Chairman’s mid-term viewpoint
Invited Speaker: Charlie Tomson

                   Carron
GLOMERULAR PATHOBIOLOGY AND PROTEINURIA
(Renal Science)
Chair: Bruce Hendry and Moin Saleem

Mesangial Cell Biology and Glomerular Disease
Invited speaker: Josef Pfeilschifter, Professor and Dean of Medical School, University of Frankfurt, Germany

O25 Podocyte angiopoietin-1 overexpression perturbs glomerular integrity resulting in albuminuria
David Long, Post Doctural Research Fellow, UCL Institute of Child Health

O26 T-Type Calcium Channel Blockade inhibits mesangial cell proliferation in vitro and in vivo
Andrea Cove-Smith, Renal Research Fellow, King’s College London

O27 Angiopoietin-1 improves the ability of glomeruli to retain albumin
Andy Salmon, Clinical Lecturer in Renal Medicine, University of Bristol

O28 Human podocytes possess primary cilia, which may be dependent on nephrin expression for normal function and morphology
Ania Koziell, Advanced Wellcome Fellow, Institute of Child Health, London

               Dochart DIALYSIS
Chairs: Wendy Brown & Paul Warwicker

O29 Elevated Osteoprotegrin is associated with mortality in CKD 4 and 5 patients independent of vascular calcification
Mhairi Sigrist, Renal Research Fellow, University of British Columbia, Canada

O30 Application of bioimpedence techniques to assess extracellular fluid status in patients attending a satellite HD unit
Y Mun Woo, Associate Specialist, Inverclyde Royal Hospital

O31 Near-subject absolute and relative measures of total body water (TBW) provide added information in the change of body composition and hydration status of HD patients over time
Cian Chan, Specialist Registrar, University Hospital of North Staffordshire

O32 One year changes in nutritional status of patients with Encapsulating Peritoneal Sclerosis
Nevine El-Sherbini, Specialised Renal Dietician, Hammersmith Hospital

O33 Repeated episodes of HD induced Myocardial Stunning lead to Myocardial Hibernation and reduction in Overall Systolic Function
James Burton, Research Registrar, Derby City General Hospital

O34 HD induced Myocardial Stunning is associated with a reduced 12-month survival
James Burton, Research Registrar, Derby City General Hospital

17.45-18.45                                                                                                                                           Lomond Auditorium
Chair: Kevin Harris
The impact of renal dysfunction and anaemia in CV outcome trials
Invited Speaker: John McMurray, Professor of Medical Cardiology, Division of Cardiovascular Medicine, University of Glasgow
18.50-20.00 WELCOME RECEPTION IN THE EXHIBITION AREA